Searchable abstracts of presentations at key conferences in endocrinology

ea0029s41.1 | The endocrinology of adipose tissue | ICEECE2012

Physiological and neuronal determinants of brown adipose tissue-mediated thermogenesis in small mammals and humans

Richard D.

Brown adipose tissue (BAT) is a thermogenic organ. Its tremendous thermogenic potential is conferred by uncoupling protein 1 (UCP1), which dissociates ATP synthesis from energy substrate oxidation and thereby insures heat production. BAT represents a key thermogenic effector implicated in thermoregulatory thermogenesis. The physiological control of BAT activity and capacity is ensured by the sympathetic nervous system (SNS), which densely innervates brown adipocytes. SNS-media...

ea0081p49 | Calcium and Bone | ECE2022

Extended treatment with recombinant human parathyroid hormone (1-84) in adult patients with chronic hypoparathyroidism: a phase 4 study

Rubin Mishaela , Cusano Natalie , Yin Shaoming , Tokareva Elena , Ayodele Olulade , Finkelman Richard D.

In Europe, rhPTH(1-84) is an approved adjunctive treatment for adults with chronic hypoparathyroidism that cannot be adequately controlled with conventional therapy. Here we present data from the longest rhPTH(1-84)-treated study cohort of patients with hypoparathyroidism. In a single-centre, single-arm, phase 4 study (NCT02910466), long-term rhPTH(1-84) treatment (25, 50, 75, or 100 μg/day subcutaneously) was evaluated in adults with chronic hypoparathyroidism who mainta...

ea0021p354 | Steroids | SFEBES2009

Low testosterone and androgen receptor insensitivity results in decreased AMP-activated protein kinase activity (AMPK) in the liver in the testicular feminised (Tfm) mouse

Igreja Susana , Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones T Hugh , Korbonits Marta

There are controversial data on the beneficial/detrimental effects on the cardiovascular as well as on the metabolic system by the sex hormone testosterone. Recent data support the hypothesis that low levels of androgens are associated with adverse cardiovascular risk factors including an atherogenic lipid profile, obesity, insulin resistance and hypertension. AMPK is a sensor of energy balance at both the cellular and whole-body level. Once activated by low energy status, it ...

ea0014oc6.2 | Cardiovascular endocrinology | ECE2007

Testosterone replacement attenuates fatty streak formation and improves the HDLC profile in the Tfm mouse: an effect which is independent of the classical androgen receptor

Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones Hugh T

Research indicates that low testosterone is associated with CAD in men. Evidence suggests that men with hypotestosteronemia and concomitant CAD may benefit from physiological testosterone replacement therapy (PTRT). The mechanism by which testosterone produces these cardio-protective effects and the role of the androgen receptor remains largely unknown. The aim of this study was to determine whether testosterone modulates atheroma formation via its classical signalling pathway...

ea0013oc37 | British Thyroid Association Award | SFEBES2007

Testosterone replacement attenuates fatty streak formation and improves the HDLC profile in the Tfm mouse: an effect which is independent of the classical androgen receptor

Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones Hugh T

Research indicates that low testosterone is associated with CAD in men. Evidence suggests that men with hypotestosteronemia and concomitant CAD may benefit from physiological testosterone replacement therapy (PTRT). The mechanism by which testosterone produces these cardio-protective effects and the role of the androgen receptor remains largely unknown. The aim of this study was to determine whether testosterone modulates atheroma formation via its classical signalling ...

ea0041oc12.4 | Obesity | ECE2016

GLP-1 directed delivery of dexamethasone ameliorates hypothalamic inflammation and reverses diet-induced obesity

Quarta Carmelo , Clemmensen Christoffer , Yang Bin , Zhu Zhimeng , Muller Timo D , DiMarchi Richard D , Finan Brian , Tschop Matthias H

Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...